4/12/2023 0 Comments Levothyroxine 125 mcg![]() Thyroid replacement therapy should be introduced gradually in elderly patients, and those with severe long standing hypothyroidism. To minimise the risk of adverse effects of undetected overtreatment, such as atrial fibrillation and fractures associated with low serum levels of thyroid stimulating hormone (TSH) in older patients, it is important to monitor serum TSH and adjust the dose accordingly during long term use. Thyroid treatments should be used with caution in patients with cardiovascular disorders, including myocardial insufficiency and hypertension. If necessary, Levothyroxine Oral Solution can be administered via a nasogastric feeding tube that should be rinsed twice with 10 ml of water immediately after administration. Rinse the syringe and replace the cap on the bottle (PIBA remains in place). Repeat steps 2 to 4 as needed to achieve the required dose.ĥ. Discharge the syringe contents into the mouth. Remove the filled syringe from the bottle in the upright position.Ĥ. Insert the syringe into the PIBA and draw out the required volume from the inverted bottle.ģ. Open the bottle and at first use insert the Press-In Bottle Adaptor (PIBA).Ģ. If no discernible decrease in size of the goitre occurs after 6 to 12 month, thyroxine therapy should be stopped.Ī graduated oral syringe and a Press-In Bottle Adaptor (PIBA) are provided with the product.ġ. Infants should be given the total daily dose at least half an hour before the first meal of the day.ĭuration of treatment is usually for life in the case of hypothyroidism, non toxic goitre and goitre associated with Hashimoto's thyroiditis.įor patients with non toxic diffuse goitre and normal T4 and TSH levels treatment with levothyroxine can be considered. The dose should be increased gradually every 2 to 4 weeks according to the clinical findings and thyroid hormone and TSH values until the full replacement dose is reached. Thereafter, the dose should be adjusted individually according to the clinical findings and thyroid hormone and TSH values.įor children with acquired hypothyroidism, the initial recommended dosage is 12.5-50 micrograms per day. The maintenance dose is generally 100 to 150 micrograms per m² body surface area.įor neonates and infants with congenital hypothyroidism, where rapid replacement is important, the initial recommended dosage is 10 to 15 micrograms per kg BW per day for the first 3 months. ![]() A dosage, lower than optimal dosage giving complete replacement therapy, consequentially not resulting in a complete correction of TSH level, might therefore need to be considered. a gradual increment of 12.5 micrograms/day fortnightly) with frequent monitoring of thyroid hormones. ![]() In elderly patients, in patients with coronary heart disease, and in patients with severe or long-existing hypothyroidism, special caution is required when initiating therapy with thyroid hormones, that is, a low initial dose (for example 12.5 micrograms/day) should be given which should then be increased slowly and at lengthy intervals (e.g. The recommended dose is 150-300 micrograms/day. The recommended dose is 50-200 micrograms/day. The initial dose is adjusted by 25 to 50 microgram increments at 3 – 4 week intervals until clinical response and measurements of plasma thyroxine and thyroid stimulating hormone indicate that the thyroid deficiency is corrected and a maintenance dose established.ĭiffuse non toxic goitre or goitre associated with Hashimoto's thyroiditis 50 - 100 micrograms daily before breakfast. ![]()
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